There's some research showing that estrogen/androgen receptor signalling plays a part in sex-differential disease severity in SARS-CoV-1 and SARS-CoV-2. Incidentally, i love how some suggested pharmacotherapeutic agents include, like, nonsteroidal antiandrogens, GnRHa's, straight-up estradiol, and, of all things, spironolactone.

https://cancerdiscovery.aacrjournals.org/content/10/6/779

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450662/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233687/

https://journals.physiology.org/doi/full/10.1152/ajplung.001...

https://www.medrxiv.org/content/10.1101/2020.08.21.20179671v...

https://www.jimmunol.org/content/jimmunol/198/10/4046.full.p...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191632/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363620/

https://link.springer.com/article/10.1007/s11906-020-01073-x