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I've been trying some of the David Sinclair NMN + resveratrol stuff for a couple of months. I think I can safely state there has been no noticeable effect in my case. There's a guy on the internet been trying it for 6 months with seemingly some positive effects https://www.youtube.com/watch?v=yWx77ARQ9lo And it seems to do stuff in mice.

https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-...

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Mouse models are just that. Models. A lot of the results in mice don't carry over to humans. A positive result in mice is only weakly indicative of potential efficacy in humans. [1,2] Pop-sci articles seldom acknowledge this or draw attention to this.

Re reservatol, the jury is really out on that one too. [3,4]

[1] https://theconversation.com/of-mice-and-men-why-animal-trial...

[2] https://www.nature.com/news/chilly-lab-mice-skew-cancer-stud...

[3] https://www.bostonmagazine.com/health/2019/10/29/david-sincl...

[4] https://www.health.harvard.edu/blog/diet-rich-resveratrol-of...

Yeah it's a bit hard to tell either way - works or does nothing much. The enthusiasts like Sinclair take DNA methylation tests which seem to indicate some effect but whether that translates to longer life I dunno. I've been too tight to try those as they tend to run $300 per test.

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