Amateur-built experimentals have achieved upwards of 50 mpg in realistic flying conditions, but they generally tended to be tandem-seat designs with minimal frontal area and low-powered engines.
More recently, the Pipistrel Taurus G4 (a highly modified sailplane with an electric motor between twin fuselages, designed to carry a pilot and three passengers) achieved just over 100 mpg at ~107 mph.
I eagerly await proof that the Celera--a significantly larger, heavier, and faster aircraft than Rutan's Catbird--actually achieves similar fuel economy. If true, it would be a pretty incredible leap for an industry that's been largely stagnant for decades, but these sorts of claims have a long history of being either sadly mistaken or outright fraudulent.