More importantly, this is a part of the larger narrative that everything has been caused by overprescribed opioids. However, there's no correlation between increased prescriptions and increased illicit usage [0]. Rather, it seems there's been a large growth over time of illicit opioid use [1]. The only place this sort of thing has been effectively combated is in Portugal due to its decriminalization and attempts to make things safer. Politicians caused this with their stupid "war on drugs". They are now pointing and saying, "Look, the big bad Sacklers did it!" so their own failures are ignored. Stop scapegoating one family for a political and societal issue.
0: https://www.researchgate.net/publication/330922982_Today%27s...
1: https://www.sciencedaily.com/releases/2018/09/180920161028.h...
All that said, I generally favor your stance that ending prohibition would yield the greatest harm reduction.