In my feed, the highest signal to noise ratio comes from people who aren't commenting on any and every trending topic. Instead, they're busy doing real work, away from Twitter, only occasionally checking in to share something. Likewise, that's how I try to structure my own engagement.
When people have 50 Tweets per day or more, it's unlikely that they're taking time to really think and engage. It's more about rapid fire comments designed to get the most engagement.