Are drones anywhere near as fast as a missile? In certain situations, an F/A-18 under afterburner can outrun a SAM missile - outrun meaning go fast enough that the missile can't close the distance before it runs out of fuel. How much chance would a drone have of catching it even while not operating under afterburner?
https://en.wikipedia.org/wiki/McDonnell_Douglas_F/A-18_Horne...
The unclassified ceiling is 50,000 feet, with a 250 m/s climb rate. Could a drone strapped with explosives come anywhere near that level of performance?