TED talk about "Open Science" debate TEDxWaterloo
wired.com
wired.com
The main blockers of open science will probably be paper publishers and commercially funded science. For publishers, it's easy to see why: their market will be reduced to only peer-reviewing services. For commercially funded research (especially political commercial science): It's in their interest not to share the data. Because sharing it would allow critics to scrutinize the data and filter out the ugly.