Nasal vaccine against Covid-19 prevents infection in mice
medicine.wustl.edu
medicine.wustl.edu
> Many microbes, including the coronavirus, enter the body through the mucosa — wet, squishy tissues that line the nose, mouth, lungs and digestive tract — triggering a unique immune response from cells and molecules there. Intramuscular vaccines generally do a poor job of eliciting this mucosal response, and must instead rely on immune cells mobilized from elsewhere in the body flocking to the site of infection.
> Given the potency and rapid spread of the coronavirus, some say it makes sense to develop vaccines for the airway as well as the more standard jabs. “Knowing how potent mucosal responses can be against a viral pathogen, it would be ideal to be thinking about mucosal vaccines,” said Akiko Iwasaki, an immunologist at Yale University.
https://www.nytimes.com/2020/07/14/health/coronavirus-nasal-...
And here’s one of the first studies using a mouse model (AFAIK) for SARS-CoV-2 if you want to see how that works: https://rupress.org/jem/article/217/12/e20201241/151999/Mous...
It does seem like they do an especially good job at blocking infections in the respiratory system, but that's both the system that they primed for infection and where they provided the ChAd vaccine, so I don't know how fair of a comparison the intramuscular injection experiments are.
This vaccine has not been tested in chimpanzees (and actually such experiments would probably be a challenge, since they may have existing immunity to the backbone adenovirus).
(edit: parent comment initially mentioned experiments in chimpanzees rather than mice)
In something like administering naloxone or I suppose CPR training, or even just educating people about the Heimlich Maneuver, it seems like a key contributor is that an immediate response by someone on the scene of an emergency is critical. The expectation is "if you happen to encounter such an emergency, you're now able to do something to help". What you're suggesting seems qualitatively different -- proactively sending out non-healthcare-providers to administer something to people before they get sick.
And yet, if we want to administer it to billions of people quickly, maybe that will be necessary. I also wonder if that will be the bottleneck, or if producing/distributing everywhere it will be.
A large part of the movement IMO stems from the fact that subconsciously, humans tend to associate long sharp needles = pain = bad
That doesn't seem to stop anti-vaxxers: https://www.latimes.com/world-nation/story/2019-09-04/anti-v...
It's staggering the number of expats here posting about Bill Gates, globalists, and a terrorist conspiracy to take over the planet by pretending Covid is a danger when it's not.
I don't think it's fear of needles or any logical aversion to something scary.
It's people who base their core beliefs on no evidence or tertiary sources, and therefore no evidence can be used to convince them otherwise.
I knew people like this are out there, but this has been like a gut punch.