Usually it is nothing to worry about, except when you get obsessed by it and it starts to control aspects of your life because you build a worldview around it or try hard to avoid it or explain it away: then it is called an existential crisis. But what it really means is that the mind gets overwhelmed by the fact that the universe is orders of magnitudes more complex than what the self has ever encountered in our daily lifes. Our brains have evolved so that bipedal apes that migrated from forests into the steppes can survive and cooperate in groups. It was never meant to be confronted by questions of this dimension, but yet here we are.
You can make your peace with it, and embrace it. It can also be a source of endless curiosity, spirituality and creativity.