- If you've got a low-dimensional problem, say 2D or 3D, without uncertainty (or at least bounded enough to pad obstacles and ignore it), search-based planners like A* and its derivatives work. Add uncertainty, complex non-holonomic constraints, limited horizons, etc and it becomes much harder.
- If you've got a higher dimensional problem, say a 6/7-DoF arm, even multi-armed or humanoid robots, and you don't have uncertainty and dynamics (or can ignore them), sampling-based planners like RRTs and PRMs and their derivatives will often practically work. Actually useful guarantees of finding a solution or trying to find an optimal solution in useful time are still very much unsolved.
- If your problem is basically open, and something approximating the "straight-line" from A to B is in the same local minima as a solution, trajectory optimization will work for a lot of problems. Motion planning is very much non-convex, though, so it's very easy to go from a problem solvable with optimization to a problem that isn't.
- Planning with non-rigid objects, significant uncertainty (effectively continuous MDPs or POMDPs), and/or complex dynamics are all very unsolved problems.
For motion planning problems in the gray area of "practically solvable", the art is figuring out how to simplify the problem as much as possible to make it tractable - highly optimized collision checking (generally speaking the performance bottelneck), combining search/sampling-based + optimization methods to get an initial solution from a global method and then refining it towards a local minima with optimization, or using special hardware or sensors to bound dynamics and uncertainty so it can be ignored.