Ask HN: Is CLI pronounced C-L-I or “clee”?
When talking about a command-line interface (CLI), do you say "clee" or C-L-I?
But steering the sentence to say "command line" might be even more idiomatic. That is:
"It would be fastest to delete that directory tree from the command line"
would be preferred to:
"It would be fastest to use the C-L-I to delete that directory tree"