Its quite possible to build an AMD-Hackintosh, its quite in stlye really.
1. Really bad VM support. No Hypervisor framwork, which means problems with Docker (apparently some workarounds for Docker specifically, but not 100% stable). Things like Parallels Desktop, Android VMs, etc won't work.
2. Problems with Adobe suite apps crashing on boot. Some patches exist but last I checked there was nothing for Lightroom (which I use a lot).
3. Things like iMessage, Facetime, Siri, etc won't work
4. Uses a custom kernel and there can be hassles related to power management.
etc.
My use case would have lots of problems, but it's definitely a great option for people who don't need VMs or Adobe.