The supplements came after I saw my genetics and from past anecdotal experiments. But maybe start by understanding the electron Transport chain. When I saw all the oxidative stress created there I began looking at the several pathways for the flow of O2- and H2O2. To me, mood disorders have their root in this flow being unobstructed.
Riboflavin ended up being big for me for several reasons.
Keep in mind, mood disorders are polygenic, may causes, so for you it might be something with Monoamines or what ever.
I wish doctors would get serious about testing for these deficiencies in people wit mood disorders...