One of my ex bosses had a liver transplant and it meant the rest of his life was spent consuming pills to prevent his immune system from attack the donor liver. I only found this out when I asked a colleague why did he smell funny. Having tried raw liver myself and experiencing the stimulating energising effects compared to cooked liver, I wonder how much folded proteins created by cooking food contributes its own problems. In some cases, if a folded protein gets into a cell, the only remedy for the cell is to have the immune system destroy it. That puts a demand on stem cell generation to fill the void. Its been suggested sweating is the 3rd kidney and that spending 15mins in a 80DegreesC sauna can sweat more toxins than the kidneys can excrete in a 24hr period. Its looking like our sedentary air conditioned office lifestyles could be more harmful than we first thought.
I have found it interesting that Methylation is now being looked at as another form of antioxidant process especially when considering its relationship to cancer progression. When looking at the methylation processes, its clear even the most organic of diets dont contain enough molecules for us humans to maintain healthy methylation, probably because the host animal or plant needs the same molecule to maintain its own life, thus leaving little else for us to use. What constitutes "essential" nutrients is certainly being reconsidered now a days.