Debugging was a pain because of you were writing JavaScript rather than Obj-C and the line or file on some errors were on were entirely unhelpful.
Performance (which you don't notice in the simulator) is poor. I was working with tables on iOS, even after cutting the app down to using 10 rows, people noticed a lot of lag on iPhone 4s (and it was unusable on a 3G or 3). This was with the only scroll events being a scroll position check suggested by the KitchenSink demo they provide.
Entirely possible this was something I missed, but while it says cross-platform, you don't really get cross-platform. The difference in UIs between Android and iOS means you're going to be writing quite a lot more code to actually get an app that works on both Android and iOS.
[edit] syntax