That font is hideous! It only extenuates the bottom of the text, especially on capitals which don't need enhancing because they're already in CAPS. Paragraphs of text in caps just become noise, blocks of letters rather than words.

That font also looks like the top of the line has been rubbed off, making things far worse as the top of the text has cues to recognise words. I believe that's my issue with caps as it makes words hard to read as I see blocks of letters, not words.

The biggest change I make the text easier to read is to increase the font size a couple of points or zoom in a little (ctrl + mouse wheel/ +-). Right now hacker news is at 150% zoom (snapped to the left side of a 43" 4K monitor).

Also, I prefer not use windows scaling as it wastes a lot of pixels with bigger menu bars (my eyesight is fine). One more thing... I'm very particular about the screen brightness (there's an app called clickMonitorDDC that let's you change screen brightness from mouse wheel or keyboard (crtl+shift+ up/ down)), and blue light filter at night. I find I can focus better in the evening/ night but I believe that's more of an ADHD thing.