My latest favorites that I'm a bit more hopeful for are glycine, spermadine, and rapamycin.
Sounds more than a little dangerous, unless you have an illnes like Lupus that activates mTOR, and even then I'd be nervous taking this drug without expert medical supervision!
On the upside, my partner has a Lupus-like autoimmune disease, so this drug will be an interesting one to track.
Personally, I do think it can likely be taken pretty safely if monitored reasonably, and I am pretty hopeful for it as well. But it's true it's a serious drug so it shouldn't be messed around with as if it's a game.
Serious questions: have you experimented with calorie restriction? Clearly thats THE method that works in every species. Second question: do you battle with depression? My current hypothesis is that any life extending drug will also inevitably lead to depression given the links shown between the sirt1 pathway and depression (also potentially as an evolutionary check but that's just me throwing ideas out).
I have before, but I would say it's not too bad right now.
I'm interested in it's benefits for autoimmune diseases but it seems quite expensive (in the US).
It's a hard area to give advice in since everyone is different, so I can't really offer much besides that I think for the best return, someone has to spend a lot of time doing their own research and testing and so on to find out what works for them
Do you make an effort to get large doses of these things from food first?
Since I tested all of my blood metrics beforehand, it's unlikely the market would have a 'perfect' vitamin for me. Especially since most of what I like to take isn't technically a vitamin.
My diet is currently pretty un-optimized, so although I would prefer to consume a lot of things via diet, it's not guaranteed at all. But the extra bio-availability and such is likely nice
Daily intake of, tomato juice, kefir, sardines, salmon, spinach, sunflower seeds, pumpkin seeds, pistachio, eggs. You could probably get a whole days worth of food into a snack, a salad, and a soup.
I do know there are a few people in the area that log literally every substance they eat in terms of grams, and then correlate it with all of their blood metrics, and use that to try to optimize each blood metric for what correlates with the lowest mortality rate. It's interesting, but this stuff is unfortunately a lot of work for average people to attempt. Here's a great example: https://twitter.com/Nearcyan/status/1282042301980835842