I know it's obvious, but it feels like it's only obvious to those that think about security. It's the same reason that putting your developers through a yearly OWASP Top 10 secure coding course isn't going to get you to 100% secure code.
Locking down systems seems draconian, but it's the only way:
- Disabling USB storage
- Moving away from passwords to hardware authentication
- Strong controls on internet access
- Stop incoming calls from reaching most employees. Better: take away phones altogether
And so on.