I think this concern is overblown. It certainly hasn't stopped Canada and Mexico from negotiating the USMCA trade agreement, for example.

The JCPOA (more commonly known as the Iran deal) constrained Iran's nuclear program, and it was with great disappointment that I watched the administration withdraw. But there were anecdotal reports of transgressions on Iran's part, and the JCPOA was never submitted to the US Senate for ratification, which means it was never a legally binding agreement under U.S. law. Like the Paris climate agreement (most of its signatories saw their GHG emissions increase, but not the US; so much for the effectiveness of such agreements to achieve concrete progress in the fight against climate change).