A combo of fasting plus vitamin C is effective for hard-to-treat cancers in mice
sciencedaily.com
sciencedaily.com
I think the reason this "entirely unexciting" study is getting attention is related to one of its author's having a talent for self-promotion.
> Longo is the founder of and has an ownership interest in L-Nutra; the company's food products are used in studies of the fasting-mimicking diet. Longo's interest in L-Nutra was disclosed and managed per USC's conflicts-of-interest policies. USC has an ownership interest in L-Nutra and the potential to receive royalty payments from L-Nutra. USC's financial interest in the company has been disclosed and managed under USC's institutional conflict of interest policies.
The most ingenious business scheme ever devised: a mail-order fasting diet.
Most treatments studied are patented drugs, I never see these types of comments about those.
Apparently when fasting (or fasting mimicing) our bodies start burning fat cells, removing old unused white blood cells, generating stem cells, and a lot more. In a study with monkeys, the group that was fed 25% fewer calories ended up living a lot longer and having fewer diseases. Longo advocates doing a fast-like diet for a week twice a year in healthy people and potentially more for people with certain health issues.
Could you please explain what this means, for the uninitiated?
In general IF (intermittent fasting) is a catch-all phrase, and not a particularly helpful one.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938162/
Quick take from the abstract: "The vulnerability of cancer cells to nutrient deprivation and their dependency on specific metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) lead to wide alterations in growth factors and in metabolite levels, generating environments that can reduce the capability of cancer cells to adapt and survive and thus improving the effects of cancer therapies. In addition, fasting or FMDs increase resistance to chemotherapy in normal but not cancer cells and promote regeneration in normal tissues, which could help prevent detrimental and potentially life-threatening side effects of treatments. While fasting is hardly tolerated by patients, both animal and clinical studies show that cycles of low-calorie FMDs are feasible and overall safe. "
Like saying "I don't have time to take a shower, because my bath takes an hour"
I honestly don't know how this link could be explained any more, so shrug.
In the same interview he explains the whole mask debacle, which it seem the USA has 100% reversed months after this interview, as he predicted. "mAh FrEeSpeCh" I guess.
The IDW constantly touts the need for experts, who stand in the face of political correctness, while hypocritically not being experts themselves in the subjects they always want to talk about on public platforms.
To relate this back to technology, it's very similar to designing apps. Everyone feels like they are an expert app designer, simply because they can identity that something feels off about an app, and because they use apps everyday. In fact, they aren't expert app designers, and they are simply identifying problems that most people can identify, and have no real solutions to offer. But because the pain of using the app is shared by many people, a lot of people latch on to loud mouth non-experts for pointing out the obvious and making them feel smart.
I've been politically engaged for decades and this is the first time I've been terrified about the outcome of an election.
What if it's fasting + being cold + Vitamin F + whatever new thing your molecular simulation just suggested?
The role of cellular autophagy is not that clear: it can promote mammary and pancreatic cancerous cells survival but on the other hand its inhibition promotes the development of lymphoma for instance.
Apoptosis can likely have a symmetrical role.
It isn’t clear neither that this behaviour is consistent across all development stages of given cancers.
What?
"Wrong: Why Experts Keep Failing Us"*
David H. Freedman lists "Eleven Simple Never-Fail Rules for Not Being Misled by Experts". One is:
>"It's supported by ... animal studies. ... I recommend treating as interesting fantasies any claims for human health or behavior that are based entirely on animal studies."<
> For vitamin C experiments, mice undergoing standard feeding or at the last day of the first FMD cycle started to be treated with vitamin C (4 g/kg in saline) via intraperitoneal injection twice a day, every day until the end of the experiment. At least 6–8 h have elapsed between the two administrations in each day.
EDIT: 4 g/kg twice a day is about 400 grams (0.88 pounds) of Vitamin C per day for a 50 kg (110 pound) person. 1 gram per day is a good rule of thumb for the upper limit of oral supplementation.
[1] https://www.nature.com/articles/s41467-020-16243-3.pdf#page=...