BTW has any country with good contact tracing posted any details about where most people get infected? I can't believe we're 6 months into this and still don't know if grocery shopping is risky or not. In the US I read all the updates but still dont know who is getting infected or where.
Accordingly, most infections occur at private parties, in indoor restaurants, and in crowded factories, like meat processing plants.
I wrote a 10 min post on it - https://tolusnotes.com/state-of-digital-contact-tracing-in-t...
Also, they mentioned that while in the past, most case counts were from breakouts, that has changed. Now most case counts are "sporadic" cases, meaning no known infection source. The implication is that it's just out there in the general public now.
Oregon also currently has lousy test availability, at least as of a couple of days ago. One person I know seeking a test was basically denied - they couldn't even get scheduled. Something about too many tests being sent from Oregon to California and Arizona.
The most promising plan I've heard along these lines is detailed in a recent episode of This Week in Virology.[2]
This is possible, practical, and affordable.
The technology for fast pregnancy-test style tests for COVID-19 exists right now, and they could cost as little as $1 per test.
The reason these tests aren't being used yet is because of the FDA's misguided requirements for extremely high sensitivity for COVID-19 tests. If these requirements could be relaxed to allow lower-sensitivity tests, then these tests could go out on the market... or, better yet, the government could take over and ensure everyone gets tested with these tests every day for $1 a test.
Even a more limited plan of testing everyone in just highly affected areas would be way better than what we've got now.
[1] - People could, for instance, get tested each morning, and be required to present their daily test results upon arriving at work (or even online, from home, before they start their commute). If they test positive, they just stay home for a couple of weeks and then go back to work when they test negative again. People at work will have confidence all their colleagues (and virtually everyone else out and about) have tested negative.
[2] - Starting at about 6'20" in to episode 640: https://www.microbe.tv/twiv/twiv-640/
During COVID they have really stepped up to provide clear and well grounded information to their listeners about the pandemic. Every friday they have been releasing an episode where a doctor on the front lines of the NY pandemic has given a medical update on symptoms and treatments. Invaluable information!
Antibody tests or antigen tests? I'm aware of that style of tests for the former but not the latter. You need the latter to do what you describe.
The problem is that their % positive agreement is too low (<90%), and their % negative agreement is based on the PCR benchmark which already churns out a false negative rate of roundabout 30%.
And even their positives are only reasonably reliable (<90%) during peak symptoms. If you're pre, post, or low symptomaticity, its accuracy isnt even characterized (but believed to be low.)
Given all of the above, hyping them up is ... well, ignorant of all of the above, one hopes.
The Abbott Labs test false positive rate was 0.02%, which seems totally acceptable to me
https://www.statnews.com/2020/05/15/fda-says-abbotts-5-minut...
On the other side of the equation, Mina’s point (see paper in my other comment) is that with frequent enough testing, the math of the epidemiology indicates that the sensitivity does not need to be terribly high to have a huge impact on the trajectory of the pandemic
Edit: I see now that you were talking about antibodies, not antigens, sorry
The low %positive agreement generates false negatives, though, not false positives. False positives, for this context, would be fine.
If you don't catch them on the very first day they have enough virus in their body to be above the test threshold, then you'll probably catch them in the next day or two anyway. Also, positive results can be verified with more reliable tests, if you want... or you could just retest with the same test some more, with every consistent result raising one's confidence in the test.
The TWiV episode goes in to detail about how if the goal is reducing the spread of the virus on a population level, then we only really care about a narrow window of infectivity, not about when people are infected but don't yet have enough virus to infect others. The cheap, quick tests they're talking about are good enough for this purpose.
I don't think test turnaround time is this quick in the U.S.
https://www.statnews.com/2020/05/15/fda-says-abbotts-5-minut...
If you have a factory capable putting out 350M tests/day (let's not even get in to logistics or the next steps), please hang out your shingle.
If not, then perhaps considering plans within the realm of possibility is a better use of time.
Op ed: https://www.nytimes.com/2020/07/03/opinion/coronavirus-tests...
This isn’t like PCR testing. It’s closer to insulin testing, in terms of the expense and difficulty of creation of the tests (and the means of interpreting the results). 350M is well within the range of possibility.
And the reward to having a reopened economy and significantly reduced death toll could justify very large investment.
From the above mentioned TWiV podcast[1]:
"Take every manufacturing company that knows how to print paper, adapt their tools to print monoclonal antibodies on to those sheets and just start slicing it up and shipping it out. It's as easy as that, I mean, you know, I'm simplifying it a bit, but..."
And, as the host of TWiV said in an earlier podcast[2]:
"It's not undoable. If this were World War 2, you would figure out a way to do it! This is war. This is World War C19. I don't accept excuses. I got a letter from a laboratory person who said 'You have no idea what it takes to develop and execute a test, how many people, how much this and how much that..' and I said 'You're missing the point. You gotta try. You can't say why you can't do it. This is war. Let's do it!"
In fact, I believe he's actually understating the point. This disease has the potential to kill more Americans than died in all of the wars its ever been in combined, if it hasn't already. The stakes are enormous.
Let's get it done.
[1] - from about 32 minutes in to podcast 640 - https://www.microbe.tv/twiv/twiv-640/
[2] - from about 1 hour, 47 minutes in to podcast 638 - https://www.microbe.tv/twiv/twiv-638/
to your suggestion, what is a contact tracing result look like? anonymized -> 53 persons tested positive today who had near contact with 204 persons? how does that restore trust? I can't imagine you meant non anonymized.
I see this comment a lot among friends and family, I call it ‘Blank-Checking’ because you can use it to basically shut down any argument, no questions asked.
"Thursday in King County, contact tracers tracked cases from 301 of the 672 new cases identified Wednesday. They contacted and referred 5,000 people for quarantine and testing. Tuesday's contact tracing efforts identified 15% of the cases reported Wednesday, up from 5% a week ago. The number of contact tracers working in King County will expand from 300 to 1500 in the coming week.
We continue to see a high volume of cases associated with the Home Depot on Aurora, the Wallingford QFC, and UW's fraternity row. If you have been to any of these places within the last two weeks, we encourage you to seek testing immediately.
Testing is free, takes less than two minutes, and wait-times are less than ten minutes at most testing sites across Seattle. For more information, visit covid.seattle.gov or call 206-555-1212.
Your assistance is deeply appreciated. The sooner we can contact-trace every case, the sooner we can stop the COVID-19 outbreak and return to life as normal."
As daily reporting of this sort becomes part of the rhythm of life, it will both build trust and point the way for the community and government to reach to ~90%+ contact-tracing coverage. When full contact-tracing coverage is achieved, the case count can begin to drop rapidly.
This fight can be won. Winning saves lives.