I've been doing Clojure web dev for a while but hadn't found a setup that I really liked yet. My latest approach was using Firebase + ClojureScript (for my startup[1]) which was really nice but had some significant limitations for my use case (mostly related to the ephemeral Node backend). At one point I realized that I could provide Firebase's query subscription feature using Crux[2] instead without too much effort. So I started working on Biff, and I've been using it in production for 2.5 months now. It's been a joy to use.
Also, I do think that web dev in Clojure can be a little hard to get into, due to the (appropriate) community preference for libraries over frameworks. I think there is a need for more frameworks that curate a set of libraries for you. I'd love it if Biff eventually became a sort of "Rails for Clojure" that would let anyone get up to speed quickly but would allow you to switch out the components easily as you go on.
(About the name: I named it after Biff Tannen from Back to the Future).