I enjoy games for several different reasons:
- The mental challenge of trying to win, and develop winning strategies in general. Knowing a perfect strategy, or knowing that some games are genuinely unwinnable, would diminish this. E.g. "Plague, Inc."
- Immersion in a compelling, fictitious, narrative, epic story. This pleasure is probably unaffected. E.g. the "Civilization" franchise or "Endless Space 2".
- The excitement of uncertainty. This could actually be increased by knowing that some random seeds make a game unwinnable, especially if one can't know that at the beginning of the game. E.g. "FTL".