I've even watched a few people's playthroughs and going over which cards are better than others and combo well together, and my win rate is still terrible. Just lost again this morning in Act 2 with another Defect run.
Meanwhile this guy is saying the best players are winning 99% of the time on Standard, and nearly the same on Ascension level 15? Wow.
By the way, for anyone thinking this game isn't really for you, you might want to give it a chance anyway (watch a video at least). I don't usually care for Rogue-likes, and I've been pretty tired of Deckbuilders, but I got into this game hard, pretty much immediately, after putting off trying it for forever and finally deciding to give it a chance.
One thing that really makes it awesome for me is that you know basically exactly what the enemies intend to do and how much damage they're going to do to you, so you can puzzle out how to prepare for it, should you kill this person who's going to do 18 damage to you, or reduce their strength, or build up your block to absorb it, or take the hit this round so you can go after something else, etc. If you've ever played Into The Breach, it feels a lot like that, but with RPG battles instead of a Tactical map.