Do you have a source for this? I don't know much about immunology, but I know a little bit, and I don't think it's that thoughtful of a process. We have antibodies for all sorts of diseases, certainly not just for things like smallpox. This article suggests colds are endemic because they mutate too quickly for antibodies to be effective: https://www.technologynetworks.com/immunology/news/why-dont-... but we still make antibodies for them.