They are.

1. HandyBrowser (supports handhshake): https://github.com/HandyMiner/HandyBrowser

2. TorBrowser: https://www.torproject.org/

3. Opera: https://unstoppabledomains.com/opera

4. Status.im: https://status.im/

5. Brave: https://brave.com/

6. Unstoppable: https://unstoppabledomains.com/browser

7. Blockstack: https://blockstack.org/install

Probably few more - maybe dozens.

For major DNS providers, nextdns supports handshake.

0] https://handshake.org/

1] https://nextdns.io/