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Not to defend the doctor, but common sense? Sex hormones obviously have a huge effect on behavior, and anyone who has interacted with both men and women can see these effects. I'll refer you to the following study to answer your question about "non-science based theories and treatments": https://www.bmj.com/content/363/bmj.k5094

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Not that I think "oppositional defiant disorder" is even a sound classification to begin with, but the lawyer's assertion that estrogen is not an accepted or common treatment for males with ODD is spot on. This was done solely with the intent to harm, by offending a deep and fundamental aspect of the person in question.

However “Common sense” is often wrong. That is why you can’t treat people based on whatever hunch you have. Also you would hope that common sense and basic medial ethics would make you avoid violating the Nuremberg code.

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