Plasma from exercised mice showed beneficial effects on brains of aged mice | Hacker News Reader

Plasma from exercised mice showed beneficial effects on brains of aged mice

science.sciencemag.org

38 pointsbookofjoe26 comments

See also: "Diluting blood plasma rejuvenates tissue, reverses aging in mice" (https://news.ycombinator.com/item?id=23556209)

I wonder how much of the effect shown in this study, is just an expression of the effect from the other study. Either way, you're diluting away whatever the mysterious "bad stuff" in the aged mouse's plasma is. In this study's case, it's with plasma that is from young, healthy mice, and so which presumably doesn't have the "bad stuff"; in the previous article's case, it's with saline, which obviously cannot have any "bad stuff."

>... you're diluting away whatever the mysterious "bad stuff" in the aged mouse's plasma is. In this study's case, it's with plasma that is from young, healthy mice, and so which presumably doesn't have the "bad stuff";

From the abstract: >We found that administration of circulating blood factors in plasma from exercised aged mice transferred the effects of exercise on adult neurogenesis and cognition to sedentary aged mice.

I wonder if a bone marrow transplant would have a similar effect. If it doesn't then it would give us a clue on what probably doesn't matter here.

Edit: I should've just searched. I found this: https://www.nature.com/articles/s42003-019-0298-5#Abs1

>Young bone marrow transplantation preserves learning and memory in old mice

"I COME IN PEACE" I hope some of you get the reference

I can't speak to the rigor/validity of this study, but, taken together, the benefits of exercise are amazing. If exercise was a drug, no one would believe all the benefits could be real.

Same for sleeping, healthy eating habits or socializing.

I think it's not the benefits we get from doing it that are amazing. I believe it's because we are supposed to normally feel great most of the time, but NOT doing those things that should be part of a regular human life is having terrible effects on us.

If suddenly we do right by our body, it functions correctly, and the relative difference is so huge we perceive that big gap as a fantastic gain.

Like when a head/stomach ache goes away, or when you finally have time to rest after a hard week, and you suddently feel so fresh. But that impression is what should be normal.

> Same for sleeping, healthy eating habits or socializing.

My health always deteriorates when I'm more social.

Social activities rarely complement healthy sleeping and/or eating habits, in my experience.

Results like this have been replicated in various forms for a while now, it seems reasonable to believe it is real. If you have enough money you can buy blood transfusions for this purpose, though that is whole blood (from children?), not plasma.

Easier to just find a physical activity you enjoy unless you have severe disabilities no?

Some people are apparently just not wired to enjoy physical activity. Every single time this topic comes up in a sufficiently large forum, there's an incredible array of responses ranging from "I feel like shit if I skip a workout" to "of course exercise sucks, anybody who says they enjoy it is a psycho, but I do it anyway to look good naked".

That may be right. I love martial arts and m body craves doing them. But running to me is root canal. When my wife says she actually enjoys running and not just the end results of increased endurance I think she is nuts!

That's another axis of the spectrum of such discussions. I'm not just talking about different forms of exercise, though. For me, just the feeling of inhabiting my body is vaguely uncomfortable much of the time, and significant exertion usually heightens that discomfort, in addition to often making me feel lethargic for the rest of the day and occasionally leaving me with an injury that I don't notice until the next day (when this happens, it typically takes days or weeks to fully heal). In my case, I suspect that it's a sensory processing abnormality that makes it extremely difficult for me to tell when I'm pushing any given joint/muscle/organ too far.

Sorry to hear that.

The benefits occur in addition to any benefits from physical activity iirc.

I just wish it didn't take time and effort. :)

There was a science fiction story I read once where the main character would get into an "exercise box" where all his muscles were stimulated and he came out well-muscled and fit. There was also some twist where he either couldn't afford or didn't have time to be put to sleep, so he had to endure all the pain.

(can't remember what series it was)

Hm, looks like a new job for the Silicon Valley blood boys.

Anyone else envious of the health care packages lab mice have? They get free exercise and nutrition programs, get cured of diabetes and other chronic diseases. You name it. They must have a great union rep!

Until they are put into asleep with lethal injection

Some might see legalized euthanasia as a benefit.

Really, though, I was making a sideways joke about all the "cured in mice" headlines we see on HN.

This would make for a great episode of Black Mirror.

An army of exercise slaves that are worked to death to provide precious bodily fluids for the elite class that live forever

Leave Microsoft out of this.

Isn’t that the premise in Silicon Valley where Gavin(?) has the young guy giving him blood/plasma

https://duckduckgo.com/?q=peter+thiel+blood

hmmm... The matrix, the island, and all vampire movies ever.

(I know, the matrix was energy to power computers and the island was body parts, but it's all similar)

https://en.m.wikipedia.org/wiki/Penal_treadmill

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