Our immune systems are very complex and unique! If you want to apply scientific method and improve outcomes (safety, efficacy), then there is a lot more data to collect. Sharing that data and allowing recipients to own their data, would go a long way towards improving vaccine safety and allow for customization as needed. My children have had ~minor/moderate reactions to the varicella vaccine (fluid on my son's hip joint ~2" from injection site at 23 days--ER doctors just shrug), my daughter a moderate rash. How could these be improved? Guillain-Barre is very real side effect as well. How can it be avoided? I accumulate metals easily, so Al, a potent neurotoxin hangs out in my system much longer than others (possible/probable HLA variant). Shouldn't the adjuvant for my vaccines exclude Al?

Measuring temperature & physical symptoms is a good start. It would be great if these trials would measure each recipients HLA SNPs (see GSK MERS 2009 fiasco and others), T-cells (CD4/8/57/etc), inflammation markers like C3a,C4a,TGF-b, MMP-9, and cytokines like TNF-a -- before and after each vaccine dose. Measuring for all ingredients pre-post each dose is also important because the metabolization for each component is not uniform. Stop using 2010+ technology to make vaccines & medications and then evaluating the applied result with 1990s (or earlier) methods.

So if you want to shut up 'anti-vaxxers' than collect/share the data from everyone who receives a vaccine and improve the process instead of shrouding results or conducting half-assed studies (AstraZeneca using meningitis vaccine as control instead of true placebo).