1. C#'s AsyncLocal has made a few things simpler to trace SQL queries to a request.
2. We chose to use hapi.js some 2 years ago, because we found the interface superior to Express, but I did not expect the sole developer of hapi.js to decide stop working on the project [1], and left my head scratching on what I am going to do about that.
3. TypeScript's interface sometimes feels too much like just "suggestions", and every once in a while run across scenarios that are not fully supported. One that I really dislike is that Sequelize's "where" options has no type support for the model. [2]
4. Sometimes libraries does not use async correctly, and breaks stack traces.
5. Sometimes TypeScript's generic errors can be as bad as C++.
My favorite feature of TypeScript is being able to just define types/objects in-line, but I actually like to stay on the side of caution and stability on a large project with many people.[1] https://github.com/hapijs/hapi/issues/4111 [2] (GitHub is down, or I would grab the link)
For example we used SOHU-Co/kafka-node for a while as a kafka client, until we hit some bugs that made us dig through its internals and we realised it had some deep issues. We then switched to kafkajs which turned out to be much more mature and polished, even though it was less "popular".
Sequalize in particular I think was developed in an era before TypeScript was a thing so it follows the ideals of that time, more in line with Ruby and being easy to use and malleable. We switched to using slonik for our query needs, with a more declarative and static approach, skipping ORMs and query builders altogether - just raw strictly typed queries. I think in the end its a better approach for our needs.
I guess what I'm trying to say is that TypeScript was built to be able to handle _all_ of the weird and wonderful world of JS from its most amateurish and fun, to its most solemn and strict. And it's just a matter of picking up where on the spectrum you want to operate and make your dependencies match that vibe. It's limiting and freeing at the same time.
I feel like I have been to hell and back with ORMs, between Sequelize, Entity Framework, Hibernate, SQLAlchemy, etc.. and frankly, I think they just cause more headaches than solve problems.
I would love to have strongly typed SQL queries, but I have found that Dapper [1] fills a special place in my heart.