Now I'm imagining Bill Watterson's take on Cyanide and Happiness
Third in line would be either the Gaston universe (Franquin) or Goscinny's oeuvre (Lucky Luke, Asterix)
The same sort of joke would be a throwaway or interstitial gag in an animated show like Family Guy, Bob's Burgers, etc.
It's a funny quip, play on words, or ironic situation and it earns a smile or an exhale, but it's hard for me to see what makes it so special.
With the obvious exception of The Simpsons, this kind of humour was quite rare for its time. With the explosion of the internet (especially memes) and various animated shows it's now pretty ordinary.
I'd be surprised if most of the modern famous animators (Trey and Matt, Seth MacFarlane, etc) weren't fans of The Far Side.
But as the other commenter argues, at the time it stood out. I'm perhaps a bit too young to have experienced The Far Side in its heyday, but I vividly remember the truly awful cartoons I'd read in the various newspapers I'd find in my day to day. Garfield was probably one of the better ones, and IMO Garfield is pretty shit, at least in hindsight. And yet I remember having Garfield collection books.