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How does this compare to the wasm based approaches? (eg Pyodide)

Pyodide is a science-oriented suite, it's more than python. I haven't tried it, and it seems way too big, and seems too complex to build and/or use.

Brython provides some interfacing with the DOM, which is mandatory if it's replacing javascript.

Re using Pyodide outside the Jupyter stack, the documentation has some things about that: https://pyodide.readthedocs.io/en/latest/using_pyodide_from_...

It seems easy to consume from the JS app POV, if you are using the builds from upstream.