Give up (at least temporarily) everything listed - eval(), locals(), REPL etc and it still is going to be extremely useful for, arguably, most of the real use cases. E.g. I personally haven't ever needed any of these. REPL happens to be handy occasionally to quick-check something but I can hardly imagine it being used in production, it only seems useful in development time and for education. eval() seems a big red flag everybody should avoid at all cost.

Please do your best to support all the latest syntax though. Lack of support for some standard functions particularly hard to implement is Ok, lack of support for syntactic elements (e.g. type hints) is worse and, usually, easier to fix.