I learned the Dvorak layout in 2002 and have used it ever since. I have never met anybody else in real life who has bothered though!

I type letters 8-fingered. My little fingers press the meta keys and Return. This might affects my typing speed a bit, but I type at 75+wpm, which is about as fast as I can think of anything worth typing.

I used dvorak for a few years and greatly enjoyed it. Ended up back on qwerty because I was switching around to too many machines and couldn't necessarily install a driver on all of them.

I tried Colemak recently, but my grey cells are brittle and I couldn't make the leap. Not due to any problem with Colemak, but with me I think.