changes = downtime. Has been since the advent of computing
But well, no QA effort is complete enough to really assure the quality of a large system. Thus, the GP holds true.
Testing something 100% has diminishing returns.
Therefore -> you will never be able to prevent all issues. As you are not aware how many changes are happening, you don't have a value which could indicate the healthiness of it.
I personally think that when i'm getting older and better in my job, i still make errors, the amount and severity is going down though.