On a multi-collaborator large system with half the behavior off in AWS?
You're either dreaming, or haven't worked on anything complex enough to see it yet. E2E means system test, whether or not you think it is, including back end. In almost any real software in 2020 that means multiple debuggers, monitors, logs, god knows what.
But if you're testing a monolith, sure. Your system is one unit, so unit test your monolith and enjoy your debugger.
If you're testing a monolith outside of something like embedded or basic app testing, quit, because the company you're working for built a monolith.
Inactionable doesn't mean "not possible", it means "more trouble than it's worth." That's why it's advisable to do E2E on P0 cases and not really advisable to do it for P3 cases. You can do tooling work to move the bar for how much trouble you have to put in, but "try harder" misses the point.