the "like it? spread the word" header takes about ~25% of my screen and doesnt go away until i specifically put my thumb on that and scroll down. you should at least at a 'dismiss' button to permanently hide that.
after that you're in desperate need of some navigation. put a floating button somewhere which pops up the names of each column, so you're able to quickly jump to it.
the cards itself also are in desperate need of an overhaul for mobile devices. why arent the comments | discuss | url with flex space-between for example. and why is there a line at the bottom of the card?
seems to capture the spirit of tweetdeck on desktop though, so congrats on that front!
It worked fine in chrome and firefox so I thought it's good enough. I will try to fix it in coming days.