For example, the repository languages used to be at the top center of the page, while now I need to scroll past the bottom of the screen and find the information off centered in an awkward place.
The stars and other top bar links are off centered in an awkward way for the mouse and the eyes. Also, the profile tabs are less accessible because followers are now on the other side of the screen instead of in the convenient tab location.
Please contact GitHub with your feedback if you also think it's less accessible design.