For me it's the fact that all our normal stress relief outlets are shut that is the big issue. The children can't go to scouts, my daughter can't do her ballet classes and my son can't see his friends. My wife leads a few choirs which were very social, but now she has to run rehearsals over Zoom which is a pain. I'd love to go fishing or camping, but I can't. I am a radio ham, but having just one hobby available to you can get a bit dull after a while.
The biggest issue for us is our work schedules. For a few months before it all went a bit weird I had been gradually setting up my own business. A mixed bag of IT consultancy jobs and app development. I was happy with it and I had to the time to put in to it when the kids were at school. The lockdown messed all that up as my wife is a speech therapist and now has to do teletherapy from home. Unfortunately that is something she has to do during the day - thus I have to look after the children during the day. That includes homeschooling, cooking cleaning etc.
My wife has to put in a full 9 to 5 shift. It's not just a few Zoom meetings, but also note and report writing. So after she finishes work, we have dinner, a bit of family time and then if I'm lucky I might have an hour or two to work on my own things - I'm not a great evening coder.
When it all kicked off I had some plans to learn and achieve new things that I thought the lockdown would give me time to do. Stuff like learn welding, do some redecorating and learning Unity. In reality this has been the busiest period I've had since having children. Plus I've put on a fair bit of weight so that is one more thing to deal with.
That being said, we still have a good income. My wife's work is secure, in fact she is earning more with the teletherapy model. But, her employer has given up the lease on their office as they can't see a return to face-to-face working for quite some time. I have a few passive income streams. We have good family whom we can keep in tough with via Zoom etc. Putting it all into perspective we are Okay compared to some others who must really be struggling.
Edit: Plus our children's sleep schedules have gone completely bonkers.