There's a lot non-mainstream in this, like K, but partly influenced by K experience. Unusually, it's all apparently specifically designed for the job, from the processor to the operating system (only partly GNU/Linux). Notably, despite the innovation, it should still run anything that can reasonably be built for aarch64 straight off and use the whole node, even if it doesn't run particularly fast; contrast GPU-based systems. (With something like simde, you may even be able to run typical x86-specific code.) However, the amount of memory/core is surprising -- even less than Blue Gene Q -- and I wonder how that works out for large-scale materials science work for which it's obviously prepared. Also note Fujitsu's consideration of reliability, though the oft-quoted theory of failure rates in exascale-ish machines was obviously wrong, otherwise as the Livermore CTO said, he'd be out of a job.
The bad news for anyone potentially operating a similar system in a university, for instance, is that the typical nightmare proprietary software is apparently becoming available for it...