I use vimium[1] to close most pop-ups by typing "f" and then hitting the letter that pops up next to the close button.
If that doesn't work, I use a bookmarklet called "Remove Sticky"[2]. I type "bre" and hit enter when sticky things pop up to get them gone.
[1]: https://chrome.google.com/webstore/detail/vimium/dbepggeogba...