I wish Ruby had taken Python's spot. When Rails exploded ~2006, I thought it'd become a mainstream language. But sadly it has never been very popular for non-web things, if we exclude Japan.
One reason is probably that the standard Ruby implementation (MRI) was really slow till recently. Smalltalk, on the other hand, had extremely good VMs that served as embryo for the JVM.
I've used Ruby for many big projects (but never used Rails!) and it has scaled really well for large and exotic things such as abstract interpreters.