I use F-Droid whenever I can but only for NewPipe I started to actively avoid it. YouTube occasionally changes it's HTML and breaks NewPipe, the app starts crashing and while it usually gets fixed quickly and the apk gets uploaded to GitHub, F-Droid still takes weeks to update it. Last update was about 2 weeks late, that's when I uninstalled the F-Droid version and started installing it directly from the GitHub releases page. Unfortunately for time critical bug fixes F-Droid still has a lot to improve.
A useful feature you forgot is the AMOLED theme. Also subscribing to channels without having to use a YouTube account.
Some ongoing discussion on this issue thread here. https://github.com/TeamNewPipe/NewPipe/issues/1981
Upside is one less native app on my devices.
There is a hosted instance at https://invidio.us if you want to check it out, but for continuous usage I highly recommend deploying your own as it's much faster.
It doesn't really affect whether you can trust it or not, but it's probably unreasonable to expect them to deliver something they don't have.