Their point seem to be that no matter what language you prefer to be compiled to JS, in ends up being JS anyway so you might as well write JS directly, because of the reasons provided in the last post. I don't agree with them (ClojureScript is the language of choice for me), but you're not arguing with good faith here.
That being said, the commenter above them could've also been referring to old old JavaScript where no transpilation is needed to reach practically every target environment.
It seemed to me that the author was describing the (somewhat common?) practice of writing client code directly in ES5 and perhaps polyfilling any missing features for any targeted browsers that required specific fills.
I, personally, find ES6 to be ugly and requires me to pretend all sorts of things that are not true for the targeted runtime. It's like a whole fake world, so I'll prefer to avoid it unless there's some obvious reason to use it, as in an existing front-end build toolchain and a spec to use ES6, etc. Greenfield? I guess Svelte and such will use it, but if Typescripting, then one will just write Typescript, right?
I will be happy when I leave wart-land, but only when I really leave wart-land, not when it's just "lipstick on the wart"-land.
Types and classes sound nice, but only if they really exist, and not as mere compiler advice. A type is really a memory shape/size/structure in compiled languages.
Ok, having said all of this heretical nonsense...
(and yes, I've used React, Vue, etc. I tend to like Mithril best, and avoid JSX as I've no problem with hyperscript, and have even made my own lousy reactive hyperscript that I don't use (lol) in favor of Mithril)
... i DO have to say that Typescript seems like a nice/useful tool for teams, were transpiling to be accepted for the project needs, after weighing the costs/needs. I am recently rather fascinated by Svelte, and I'm mostly trying to break things and see what generated code looks like, etc. I'll admit that ES3 get's a bit useless, hence the polyfill. Minified JS with single-letter variables is usually a hoot to read.
What runtime are you using that you can't run ES6/2015 natively in the console?