But - there is a reason we've evolved to perceive reality in this way. It allows us to survive. Material concerns - health, wealth, status etc. and extractive consumption which messes up "nature", and having ego/identity distinct from nature -- all of this serve useful, vital purposes. A person who's constantly tripping will find it difficult to survive both in modern and ancient times long enough to propagate their genes.
People search for profundity in these experiences, and sure there are some. But to really understand the world and nature, I think the lens of science - observation, empiricism, and the scientific process is a better bet. There unfortunately really isn't anything _deeper_ about life. And whatever there is, personal introspection aided by psychedelics cannot hold a candle against organized human scientific endeavor.
Also, messing with one's brain is dangerous. It is one of the least understood human organs, irreplaceable, and fundamental to life like few other things.