I don't think so personally. Code size is a huge issue for page performance, and a "bytecode" format would probably be 2-3X smaller and 2-3X faster to parse. Together, this might triple JS loading speed. Maybe double the loading speed of JS heavy sites.
JS with sourcemaps isn't so different from compiled code with debug symbols. The sourcemap support could probably be adapted with minimal work. And its likely the transition would be transparent to most users, nobody really looks at the minified JS as it is.
Another big advantage is vastly simplifying JS parsing and JIT compilation. In Java and C#, most features are added without changing the code format. And when it does get updated changes tend to be minimal. Upgrading browsers and minifiers every time JS adds a language feature is a real burden on the ecosystem