The reason that it's difficult to apply in regards to the brain is that we don't exactly know how the brain is computing... or if it "computes" at all! To my knowledge, we don't have a model of computation for consciousness, emotion, free will, Etc.
Perhaps these are better classified as emergent Behavior rather than computation, but if that is the case I still don't know of a model explaining what computations or rules give rise to the emergent Behavior.
Perhaps the problem is in our definition of computation and what it means to compute.
We do know that the cardinality of the set of possible computational problems is larger than the cardinality of the set of all possible Turing machines. This is provable by simple diagonalization proofs.
The question, then, is whether or not the computations of the brain fall Within the set of Turing recognizable languages (computational problems). To my knowledge, this has not been shown.