Mind you, if Vitamin-D, magnesium and B12 play a role, that's good news for me: I've been very strict about those 3 in the past 2 years(and coincidentally loaded up my magnesium stash yesterday).
"This study was conducted under difficult dynamic circumstances and is thus limited by the small sample size, and the lack of systematic biologic measures to support its findings. It is however a proof-of-principle effort with very promising results. Our findings would need to be further validated in a well-designed randomized study."
It might give you some information if the intervention were really, really bad for patients or really really good. (So it could be used to establish possible harms). But definitely not useful farther than that except to justify larger studies.
I'm still hoping we catch a break one of these days.
Leafy green vegetables are a good source of Mg, but most people don't eat enough of those.
Also, what difference are you feeling?
Differences:
- Sleep is considerably better.
- Haven't had a single muscle cramp even after something like a 30km walk + 60km bike + gym. Otherwise a common occurrence because genetically I have incredibly strong legs and virtually no body fat on my legs.
- Generally I'm less moody and far less likely to (╯°□°)╯︵ ┻━┻ when something stupid happens at work for instance.
- No exhaustion whatsoever.
I also saw a study that said that 95% of children diagnosed with ADHD are magnesium deficient [0]! Another found a "significant decrease of hyperactivity" in children who were given oral magnesium supplements over 6 months [1].
My wrists and hands have felt better, but I've given a lot of attention to them in addition to the supplements, with more upper body workouts (on top of running 10-15 miles a week) and stretches. I'm looking to get more ergonomic tools as well. While I can't say what is and isn't due to the supplements, I don't currently see a reason to stop taking them.
[0] https://pubmed.ncbi.nlm.nih.gov/9368235/ [1] https://pubmed.ncbi.nlm.nih.gov/9368236/
As for your hands, given that you are focusing on upper body workouts maybe one up your protein intake, see if that improves things. Unless you are a vegan, Icelandic yogurt(skyr) is a pretty solid solution(the unflavored kind). In terms of consistency, I'd say it's similar to Philadelphia cheese but almost tasteless. 1 yogurt a day (350g) made a dramatic improvement in my case. Not sure about the US(judging from the fact that you used miles), but you can find those in almost every grocery store in Europe at this point for around a euro.
Unfortunately you'll struggle to reach the recommended doses because our soils are depleted and quality of crops varies wildly.
https://www.scientificamerican.com/article/soil-depletion-an...