Yesterday Adobe released a very serious advisory for Flash Player: http://blogs.adobe.com/psirt/2011/03/security-advisory-for-a... http://news.ycombinator.com/item?id=2328928
And I was thinking of the highest-profile hacking case I can remember, when Google was infiltrated primarily by vulnerabilities in Adobe software. If I recall correctly, maliciously crafted PDFs were e-mailed to staff with cleverly engineered "From" addresses and subjects. For example, an employee received an e-mail from their boss's e-mail address.