It's gotten a lot better, but we still hit tons of issues with users who don't know what Python version they installed their application in. Oh and of course our "binaries" in Scripts/bin don't seem to show up in the PATH by default. So I get to tell people "py -3.8-64 -m foo" on windows, "foo" everywhere else.

This gets much much worse when a new version of Python comes out and we don't support it yet (because of the build system issues I mentioned). I spent several weeks teaching people how to uninstall 3.8 and install 3.7 before we finally got a functioning package out for 3.8.